(3-ethoxy-2,6-difluorophenyl)boronic acid

(3-ethoxy-2,6-difluorophenyl)boronic acid - Names and Identifiers

Name	(3-ethoxy-2,6-difluorophenyl)boronic acid
Synonyms	3-Ethoxy-2,6-difluorophenylboronic acid 2,6-Difluoro-3-ethoxybenzeneboronic acid 2,6-Difluoro-3-Ethoxybenzeneboronic Acid 3-Ethoxy-2,6-difluorobenzeneboronic Acid (3-ethoxy-2,6-difluorophenyl)boronic acid 2,6-Difluoro-3-ethoxyphenylboronic acid(contains varying amounts of Anhydride) 3-Ethoxy-2,6-difluorophenylboronic Acid (contains varying amounts of Anhydride)
CAS	849035-86-5 849062-00-6
InChI	InChI=1/C8H9BF2O3/c1-2-14-6-4-3-5(10)7(8(6)11)9(12)13/h3-4,12-13H,2H2,1H3

(3-ethoxy-2,6-difluorophenyl)boronic acid - Physico-chemical Properties

Molecular Formula	C8H9BF2O3
Molar Mass	201.96
Density	1.29g/cm³
Melting Point	76-77
Boling Point	341.6°C at 760 mmHg
Flash Point	160.4°C
Vapor Presure	3.06E-05mmHg at 25°C
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.484
MDL	MFCD07369735

(3-ethoxy-2,6-difluorophenyl)boronic acid - Risk and Safety

Risk Codes	34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 3261 8/PG 2
WGK Germany	3
Hazard Note	Irritant

(3-ethoxy-2,6-difluorophenyl)boronic acid - Introduction

(3-ethoxy-2,6-difluorophenyl)boronic acid is an organic compound with the chemical formula C8H9BF2O3. The following is its nature, use, preparation and safety information:

Nature:
-Appearance: White solid
-melting point: about 120-125 ℃
-Solubility: Soluble in some organic solvents such as dimethyl sulfoxide (DMSO) and dichloromethane (DCM)

Use:
- (3-ethoxy-2,6-difluorophenyl)boronic acid is an important intermediate in organic synthesis, commonly used in the construction of aromatic compounds, the synthesis of natural products, and drug research and development.
-It can be used to synthesize phenylboronic acid compounds, such as aryl borate and potassium aryl borate.

Preparation Method:
(3-ethoxy-2,6-difluorophenyl)boronic acid can be prepared by the following methods:
1. boric acid and dichloromethane are added to a reaction flask under anhydrous and oxygen-free conditions, and trifluoroacetic acid and pyrophosphoryl fluoride are added as catalysts.
2. At low temperature, 2,6-difluoro-3-ethoxyphenyl chloride is added and reacted for several hours to obtain the product.
3. Finally, the product was crystallized and washed, and purified to obtain (3-ethoxy-2,6-difluorophenyl)boronic acid.

Safety Information:
- (3-ethoxy-2,6-difluorophenyl)boronic acid powders and solutions may be irritating to the eyes, skin, and respiratory system.
-Wear appropriate personal protective equipment such as gloves, goggles and masks when using or handling.
-When storing and handling the compound, follow good laboratory safety practices and ensure good ventilation.
-Before use, the safety data sheet (MSDS) of the chemical should be read and understood.

Last Update：2024-04-09 21:00:56